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NCT07907744
Plasma Exeresis Plus NB-UVB Versus NB-UVB Alone for Stable Vitiligo
Conditions: Vitiligo
Sex: All
Ages: 8 Years – 65 Years
Healthy volunteers: No
Phase: NA
Enrollment: 70
Sponsor: University of Faisalabad
Location: Madina Teaching Hospital Faisalabad Punjab Province
Summary
The goal of this quasi-experimental clinical trial is to compare the effectiveness of plasma exeresis combined with narrowband ultraviolet B (NB-UVB) phototherapy versus NB-UVB monotherapy in patients with stable non-segmental vitiligo aged 8 to 65 years.
The main questions it aims to answer are:
* Does plasma exeresis combined with NB-UVB produce greater repigmentation than NB-UVB alone after 24 weeks?
* Is combination therapy associated with better clinical response as measured by the Vitiligo Area Scoring Index (VASI)?
Researchers will compare plasma exeresis plus NB-UVB with NB-UVB alone to determine whether the combination treatment improves repigmentation.
Participants will:
* Receive either plasma exeresis once monthly plus NB-UVB twice weekly, or NB-UVB phototherapy alone twice weekly.
* Attend follow-up visits every 4 weeks for 24 weeks.
* Have their vitiligo severity assessed using the Vitiligo Area Scoring Index (VASI) at baseline and during follow-up.
Eligibility Criteria
Inclusion Criteria:
1. Both male and female participants.
2. Age 8-65 years.
3. Diagnosis of non-segmental stable vitiligo.
4. Vitiligo lesions located in areas accessible for treatment.
Exclusion Criteria:
1. Lesions involving the face or scalp.
2. Pregnant or lactating women.
3. History of photosensitivity or skin cancer.
4. Receipt of other vitiligo treatment within the preceding 1 month.
Source: ClinicalTrials.gov (NCT07907744). StuddyBuddy aggregates publicly available trial information.