Comparing Cross-Linked and Non-Cross-Linked Hyaluronic Acid for Early Healing After Tooth Extraction

This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. The study team measures the wound area using photographs at the time of extraction and on days 3, 7, and 14. A clinician who does not know the assigned group also assesses healing. Participants report their pain and use of pain-relief medicine. The study compares healing among the three groups.

Inclusion Criteria: * Age 18-45 years * Systemically healthy * Light smokers, instructed to abstain completely from smoking for the first 72 postoperative hours * Requiring simple posterior tooth extraction * Clinically achievable hemostasis Exclusion Criteria: * Systemic diseases affecting healing * Pregnancy or lactation * Acute infection at the extraction site * Use of anti-inflammatory or immunosuppressive drugs * Surgical extraction requiring flap elevation or bone removal