COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA

Melasma is a common acquired hyperpigmentation disorder that significantly affects quality of life. Various topical agents are used in its treatment, including Vitamin C and Niacinamide, both of which possess depigmenting properties. This randomized controlled trial aims to compare the efficacy of topical Vitamin C and topical Niacinamide in patients with melasma. A total of 100 patients will be enrolled and randomly allocated into two groups. Treatment efficacy will be assessed using the Melasma Area and Severity Index (MASI) score after 12 weeks of therapy. The findings of this study may help determine the more effective topical treatment option for melasma.

Inclusion Criteria: * 1.Patients aged 18-50 years 2.Every patient who has had melasma for more than eight weeks, according to the operational criteria. 3.A MASI score greater than 8. Exclusion Criteria: \- 1. Pregnant or breastfeeding women. 2. History of allergies, sensitivity or adverse reactions to vitamin C or niacinamide. 3\. Presence of other active dermatologic conditions like eczema, psoriasis, or acne that could confound the results