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NCT07880340
Deep TMS for PTSD With Suicidal Ideation
Conditions: Post Traumatic Stress Disorder PTSD, Suicidal Ideation
Sex: All
Ages: 22 Years – 68 Years
Healthy volunteers: No
Phase: NA
Enrollment: 72
Sponsor: D.R. Rut Zaks OHAYON
Location: Be'er Sheva Mental Health Center Beersheba
Summary
The goal of this clinical trial is to evaluate whether deep transcranial magnetic stimulation (DTMS) using the H1-coil can safely and effectively reduce suicidal ideation in adults diagnosed with post-traumatic stress disorder (PTSD). The main questions it aims to answer are: (1) Does DTMS reduce suicidal ideation in adults with PTSD? (2) Does DTMS improve PTSD symptoms?. DTMS is administered together with a brief exposure procedure intended to activate trauma-related neural circuits before stimulation.
Eligibility Criteria
Inclusion Criteria:
* Adults 22-68 years old
* Male or female
* Diagnosis of PTSD according to DSM-5 criteria
* Active suicidal ideation at screening, confirmed by the Beck Scale for Suicide Ideation (SSI)
* Able to provide informed consent
* Stable psychiatric medication regimen for at least 4 weeks prior to enrollment (if applicable)
* Able to comply with study procedures and attend scheduled sessions
Exclusion Criteria:
* Current psychotic disorder, bipolar disorder, or severe personality disorder
* Substance use disorder within the past 3 months (excluding nicotine or caffeine)
* Significant neurological disorder or history of seizures
* Contraindications to TMS (e.g., metallic implants in the head, implanted medical devices, history of epilepsy)
* Current use of medications that significantly lower seizure threshold
* Pregnancy or breastfeeding
* Acute medical illness or unstable medical condition
* Cognitive impairment that would interfere with participation (based on MoCA)
* Imminent risk requiring a higher level of care (e.g., hospitalization)
* Prior non-response to adequate TMS treatment
* Participation in another interventional study within the past 30 days
Source: ClinicalTrials.gov (NCT07880340). StuddyBuddy aggregates publicly available trial information.