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Completed NCT07872501

Clomiphene Citrate Alone Versus Clomiphene Plus Metformin as First Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome

Conditions: Polycystic Ovary Syndrome (PCOS), Anovulatory Infertility

Sex: Female
Ages: 18 Years – 40 Years
Healthy volunteers: No
Phase: NA
Enrollment: 218
Sponsor: Independent University Hospital, Pakistan

Location: Independent University Hospital Faisalābad Punjab Province

Summary

This study will compare the effectiveness of clomiphene citrate alone with clomiphene citrate combined with metformin for treating anovulation and infertility in women with polycystic ovary syndrome (PCOS). Women with PCOS who have difficulty becoming pregnant because they do not ovulate regularly will be enrolled in the study. Participants will be assigned to receive either clomiphene citrate alone or clomiphene citrate combined with metformin. The study will compare pregnancy and ovulation outcomes between the two treatment groups to determine whether adding metformin to clomiphene citrate improves the chances of conception in women with PCOS-related anovulatory infertility.

Eligibility Criteria

Inclusion Criteria: * Women aged 18-40 years. Diagnosed with polycystic ovary syndrome (PCOS). Have infertility due to anovulation. Provide written informed consent to participate. Exclusion Criteria: * Pregnant or breastfeeding women. Contraindications to clomiphene citrate or metformin. Other significant medical or gynecological conditions contributing to infertility. Use of metformin or clomiphene citrate within the preceding 3 months.

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07872501). StuddyBuddy aggregates publicly available trial information.