Evaluate of the Use of Uromune as a Potential Non-antibiotic Prophylactic Strategy for Catheter-associated Urinary Tract Infection in Patients With Long-term Catheterization.

A self-controlled pilot study to evaluate the use of oral bacterial immunotherapy for prevention of catheter-associated urinary tract infection.

Inclusion Criteria: * Adults aged ≥18 years * Long-term indwelling Foley catheter (≥4 weeks prior to enrolment) * Expected to remain catheterized for ≥6 months * At least one documented CAUTI episode or hospital admission for suspected UTI in the preceding 6 months Exclusion Criteria: * Planned catheter removal within 6 months * Ongoing systemic infection at enrolment * Immunosuppression state including: \- Primary immunodeficiency - Systemic immunosuppressive therapy e.g. steroid, chemotherapy, biologics, or immunosuppressants - Known HIV carrier or AIDS patient * Known hypersensitivity to components of Uromune