STRATHEP: AI-Driven Treatment Stratification for Advanced Hepatocellular Carcinoma

STRATHEP develops and validates a multimodal AI model to predict treatment response in advanced hepatocellular carcinoma. By integrating digital pathology and MRI radiomics, the project identifies patients likely to benefit from modern systemic therapies, using the RECIST 1.1 framework as the primary benchmark.

Participants eligible for inclusion in this Study must meet all of the following criteria: * Male or female, age \> 18 years * Hepatocellular carcinoma treated with systemic treatment during the disease course * Histological confirmation of HCC within one year of the start of systemic treatment OR the availability of an MRI of the liver within 6 months of the start of systemic treatment * Left-over tissue from previous diagnostic biopsy available * Ability to sign informed consent for secondary use of archival tissue and data collection for study-specific research for patients who are alive and that have not yet reached a 5-year follow-up period. Participants eligible for this Study must not meet any of the following criteria: * Hepatocellular carcinoma not treated systemically * Other malignancies of the liver, including cholangiocarcinoma