← Back to all trials
Recruiting
NCT07850934
Effect of Melatonin on Pulmonary Hypertension in Full Term Neonates
Conditions: Congenital Peumonia, Persistent Pulmonary Hypertension of Newborn, Congenital Diaphragmatic Hernia
Sex: All
Healthy volunteers: No
Phase: NA
Enrollment: 52
Sponsor: Ain Shams University
Location: Ain Shams University Cairo Abbassia
Summary
The aim of the study
1. To evaluate safety and efficacy of melatonin as an adjuvant therapy to inhaled nitric oxide generated by NO generator in the treatment of pulmonary hypertension in full term neonates.
2. To assess the effect of inhaled nitric oxide and melatonin on cerebral perfusion.
Eligibility Criteria
Inclusion criteria :
* Term neonates with gestational age ≥ 37 weeks.
* Mean Pulmonary artery pressure greater than 25mmHg with clinical manifestations as tachypnea, tachycardia, hypoxemia and hypotension
Exclusion criteria :
* Congenital methemoglobinemia.
* Major congenital cardiac anomalies especially duct dependent systemic circulation.
* Bleeding tendency.
* Patients on other pulmonary vasodilators
Source: ClinicalTrials.gov (NCT07850934). StuddyBuddy aggregates publicly available trial information.
