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Not Yet Recruiting NCT07845578

A Research Study Looking Into How a High Dose of s.c. Semaglutide Works With Emptying of the Stomach in People With Excess Body Weight

Conditions: Obesity, Overweight

Sex: All
Ages: 18 Years – 64 Years
Healthy volunteers: No
Phase: PHASE1
Enrollment: 60
Sponsor: Novo Nordisk A/S

Location: Medical University of Graz Graz

Summary

The purpose of the study is to determine the effect of semaglutide on gastric emptying in people with obesity. Participants will receive either semaglutide or placebo, and the treatment assigned will be decided by chance. Semaglutide is a medicine that doctors can already prescribe, while placebo contains no active medicine.

Eligibility Criteria

Inclusion Criteria: * Age 18-64 years (both inclusive) at the time of signing the informed consent. * Male or female (sex assigned at birth, inclusive of all gender identities). * Body mass index (BMI) between 30.0 - 44.9 kilogram per meter square (kg/m\^2) (both inclusive) at screening. Obesity should be due to excess adipose tissue, as judged by the investigator. Exclusion Criteria: * Known or suspected hypersensitivity to study intervention(s) (including paracetamol) or related products. * Use of prescription medicinal products or non-prescription drugs, including any herbal medicine known to interfere with the metabolic CYP pathways, such as perikon (St. John's Wort), within 14 days (or within 5 half-lives of the medicinal product, whichever is longest) of screening, with the exception of use of routine vitamins (vitamins used within a normal dose reference interval) and occasional use of paracetamol/acetaminophen, ibuprofen and acetylsalicylic acid, or topical medication not reaching systemic circulation. * Impaired liver function defined as any of the below: 1. Alanine Aminotransferase (ALT) greater than or equal to (\>= ) 2.5 times the upper limit of normal (ULN) 2. Aspartate Aminotransferase (AST) \>=2.5 times ULN 3. Total bilirubin greater than (\>) 1.5 times ULN

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07845578). StuddyBuddy aggregates publicly available trial information.