A Study of JMKX003142 Tablet to Treat Renal Edema

To evaluate the efficacy, safety, and of JMKX003142 administered randomly, double-blind, placebo-controlled study in Chinese renal edema patients with inadequate response to conventional diuretic therapy.

Inclusion Criteria: * Patients who can fully understand the purpose and process of the study and voluntarily sign the informed consent form（ICF）; * Age ≥ 18 years old during screening; * Diagnosed as renal edema during screening; * Estimated glomerular filtration rate（eGFR） ≥ 15 mL/min/1.73m2 during screening. * At the start of the run-in period,patients must have been receiving either a loop diuretic at a dose equivalent to ≥40 mg of furosemide or a combination of any dose of a loop diuretic with a diuretic of another class (different mechanism of action) as the background therapy medication. * Body weight change of \ upper limit of normal; * Patients who received diuretics or treatments with diuretic effects（except for the background therapy medication） from Day-3 to randomization; * During screening, systolic blood pressure \