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NCT07824674
The Effect of Additive On-Demand Sildenafil vs. Dextrose Candy on Maximum Exercise Capacity in Pulmonary Arterial Hypertension
Conditions: Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: No
Phase: PHASE2, PHASE3
Enrollment: 20
Sponsor: Silvia Ulrich
Location: University Hospital of Zurich, Department of Pulmonology Zurich Canton of Zurich
Summary
The goal of this clinical study is to investigate whether the additional intake of sildenafil 20mg on top of standard medical treatment results in a benefit on maximum exercise workload (Wmax) in patients with pulmonary arterial hypertension (PAH).
Eligibility Criteria
Inclusion Criteria:
* Signed Informed consent
* Age 18 - 80 years (both sexes)
* Pulmonary hypertension (PH) class I (PAH) previously diagnosed according to ESC/ERS 2022/2019 guidelines (mPAP ≥ 20 mmHg, PVR ≥ 2 WU, PAWP ≤ 15 mmHg) during diagnostic right-heart catheterization.
* Stable condition, on the same PH-medication for \>4 weeks
Exclusion Criteria:
* Severe resting hypoxia (PaO2 \
Source: ClinicalTrials.gov (NCT07824674). StuddyBuddy aggregates publicly available trial information.
