Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management

The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine can lower how much opioid pain medicine adults need after tonsil surgery (tonsillectomy) or a similar throat surgery.

Inclusion Criteria: 1. Scheduled to undergo tonsillectomy or a variant pharyngeal procedure (e.g., palatoplasty, uvulopalatopharyngoplasty \[UPPP\], expansion sphincter pharyngoplasty \[ESP\]) by a study investigator. 2. Able to understand the consent discussion in English by telephone, provide informed consent, and comply with study procedures, including completion of electronic patient-reported outcome surveys. 3. Willing and able to complete daily electronic (text message and/or email) pain surveys for 14 days and to return the dispensed opioid bottle for pill count or to respond to a telephone pill-count contact. Exclusion Criteria: 1. Chronic opioid use 2. Significant hepatic disease 3. Pregnant or breastfeeding. 4. Known allergy or intolerance to any study medication 5. Unable to complete patient-reported outcome measures because of language barrier, literacy, or infirmity. 6. Current use of a strong CYP3A4 inhibitor 7. Use of hormonal birth control and unwilling to receive suzetrigine-related counseling, given that suzetrigine may reduce hormonal contraceptive efficacy.