Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Biologics

This project will focus on rehabilitation of olfactory dysfunction in patients with chronic rhinosinusitis with polyps given biological treatment based on functional magnetic resonance imaging.

Inclusion Criteria: * Age 18 years or above * Olfactory dysfunction (i.e., a TDI score \< 30.75) * Eligible for treatment with biologics (i.e., meeting the Danish criteria for treatment with biologics (40) which includes fulfillment of the EPOS criteria for CRS. * Either treatment naïve to biologics or had their first injection within a maximum of 48 hours prior to the scan. * No other obvious explanation for the olfactory dysfunction (including, but not limited to: head trauma, sinus surgery, tumors in the nose or brain, upper respiratory infection, neurological or psychiatric disease) * Control group: normosmic at baseline (i.e., TDI-score \>30.75) Exclusion Criteria: * Previously recognized loss of sense of smell and taste due to other sinonasal or neurological conditions. * Neurodegenerative disorders known to cause olfactory deficits (Parkinson's, Alzheimer's, Lewy-Body Dementia, Amyotrophic lateral Sclerosis etc.) * Other obvious explanation for the OD (i.e., smell loss occurring in relation to one of the following (including, but not limited to): head trauma, sinus surgery, upper respiratory infection. * Contraindications for MRI scan including: * Implants or prostheses of magnetic metal * Metal foreign bodies * Pregnancy * Severe claustrophobia * Unable to complete the full MRI session. * Not able to comprehend written and/or spoken Danish language.