Evaluating the Impact of Vitamin D Supplementation on Healing Bed Sores in ICU.

To study the value of vitamin D supplementation on healing bed sores in ICU patients.

inclusion criteria: * Critically ill patients with bed sores Grade (1-2), (non-light) exudate admitted to ICUs. * Serum vitamin D \ 9. * Serum Calcium (8-10 mg/dl). * Serum creatinine less than 1.4 mg/dL. exclusion criteria: * Refusal of the legal guardian of the patient to participate in the study. * Current pregnancy or lactating mother. * Patients who are terminally ill and expected to die in less than 72 hours. * Renal dysfunction (GFR \< 30 mL/min) and the onset of dialysis during the study. * Vitamin D supplementation in the last 15 days. * Hypo/hyper-calcemia (adjusted calcium less than 8 mg/dL or above 10). * History of disorders associated with hypercalcemia (history of cancer with history of hypercalcemia within the past 1 year, hyperparathyroidism, sarcoidosis, nephrolithiasis). * History of parathyroid dysfunction. * Ongoing shock, \[defined as unstable blood pressure despite vasopressor support and mean arterial pressure (MAP) \< 60 mm Hg on at least 3 consecutive readings within a 3-hour period prior to study entry\]. * History of malabsorption syndromes; gastrointestinal intolerance (diarrhea, vomiting, or increased nasogastric aspirates). * History of adverse reaction to vitamin D supplementation. * known history of cirrhosis. * Patients taking any medications that have serious drug interactions with vitamin D like statins, orlistat, aluminum hydroxide (interfere with the absorption of vitamin D), digoxin (can enhance the effects of vitamin D on the heart leading to potential toxicity), and certain diuretics (can cause high calcium levels).