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NCT07809425
External Oblique Intercostal Block With or Without Intravenous Lidocaine Infusion for Analgesia in Patients Undergoing Gastric Bypass Surgery
Conditions: Obese Patients
Sex: All
Ages: 18 Years – 60 Years
Healthy volunteers: No
Phase: NA
Enrollment: 100
Sponsor: Menoufia University
Location: Faculty of Medicine Alexandria
Summary
Adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption (ANI guided rescue) compared to placebo, without increasing adverse events.
Eligibility Criteria
Inclusion Criteria:
* Age 18-60 years.
* BMI ≥ 35 kg/m².
* ASA physical status II or III.
* Scheduled for elective laparoscopic Roux en Y gastric bypass.
* Ability to provide written informed consent.
Exclusion Criteria:
* Refusal.
* Allergy or contraindication to lidocaine, fentanyl, ropivacaine, or any study medication.
* Chronic opioid use or dependence.
* Significant hepatic (AST/ALT\> 3× normal, cirrhosis) or renal impairment (CrCl\< 30 mL/min).
* Second or third degree AV block or significant bradyarrhythmia without pacemaker.
* Coagulopathy, anticoagulation incompatible with regional anesthesia, or infection at block site.
* Pregnancy or lactation.
* Severe psychiatric or cognitive disorder.
* Failed bilateral EOIB (absence of sensory loss in T6-T10 after 30 min) - excluded from analysis.
Source: ClinicalTrials.gov (NCT07809425). StuddyBuddy aggregates publicly available trial information.