Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators

This prospective observational study evaluates whether circulating small non-coding RNAs, particularly microRNAs, are associated with ventricular arrhythmias in patients with post-myocardial infarction heart failure who have an implanted cardioverter-defibrillator and are followed by remote monitoring. Blood samples were collected from 57 participants. Small RNA profiles are analyzed in relation to ventricular tachycardia or ventricular fibrillation episodes recorded by the implanted device. Participants are not assigned to any treatment or intervention as part of this study. The initial analysis includes six months of follow-up, with longer-term observational follow-up planned.

Inclusion Criteria: * Age 18 years or older * Post-myocardial infarction heart failure * Previous implantation of an implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator * Participation in a remote monitoring program for the implanted device * Written informed consent Exclusion Criteria: * Age younger than 18 years * Lack of informed consent or withdrawal of consent * Concurrent participation in another study evaluating a drug or therapeutic intervention