Improvement of Total Knee Arthroplasty Effectiveness Using Preoperative Prehabilitation

Sex: All

Ages: 18 Years – 70 Years

Healthy volunteers: No

Phase: NA

Enrollment: 64

Sponsor: Samara State Medical University

Location: Clinics of Samara State Medical University, Department of Traumatology and Orthopedics Samara Samara Oblast

Summary

Total knee arthroplasty (TKA) is the most effective treatment for stage III-IV knee osteoarthritis (OA). However, up to 30% of patients remain dissatisfied due to periarticular functional insufficiency, pain, and movement limitations. This study aims to improve TKA outcomes by developing and implementing a multimodal prehabilitation approach based on OA phenotypes (chronic pain, inflammatory, biomechanical) to correct clinical and functional disorders preoperatively, thereby enhancing postoperative recovery and quality of life.

Eligibility Criteria

Inclusion Criteria: * Age 18 to 70 years * Verified knee OA stage III-IV (Kellgren-Lawrence) * Intermalleolar distance ≤ 8 cm (valgus) or intercondylar distance ≤ 8 cm (varus) * Limb shortening ≤ 2 cm * BMI \< 35 kg/m² * Barthel Index \> 65 points * No decompensation of concomitant chronic diseases * No recent physiotherapy or intra-articular injections (within 1-3 months) * Signed informed consent Exclusion Criteria: * Age \< 18 or \> 70 years * Limb shortening \> 2 cm * Previous knee surgery or trauma indicating secondary OA * BMI ≥ 35 kg/m² * Decompensated chronic infectious or non-infectious diseases * Inability to comply with the follow-up schedule

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07790146). StuddyBuddy aggregates publicly available trial information.