Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity

This clinical trial will determine whether taking ascorbic acid (vitamin C), α-tocopherol (vitamin E), or both together can lower markers of brain inflammation and change the expression of neuropeptides in Mexican adults with obesity. Main Questions The study aims to answer: 1. Does vitamin C, vitamin E, or both reduce neuroinflammation? 2. Do these supplements change the expression of neuropeptides linked to obesity? Comparison Groups Researchers will compare the effects of vitamin C alone, vitamin E alone, and the combination of both to see if they improve brain health in people with obesity. What Participants Will Do Participants will: 1. Take vitamin C, vitamin E, or both daily, depending on their assigned group 2. Attend clinic visits once every 2 weeks for and tests for checkups and tests for record and report supplement intake so that researchers can monitor and evaluate treatment adherence 3. Provide samples and health information to measure inflammation and neuropeptides , at the beginning of the intervention and at 12 weeks, when the intervention ends.

Inclusion Criteria: 1. Adults aged 40 to 59 years, Mexican men and women. 2. Obese group: Body mass index (BMI) \> 30 kg/m²; body fat percentage \> 25% in men and \> 35% in women; waist circumference \> 90 cm in men and \> 80 cm in women. 3. Non-obese group: BMI \< 24.9 kg/m²; body fat percentage \< 25% in men and \< 35% in women; waist circumference \< 90 cm in men and \< 80 cm in women. 4. Willingness to sign the informed consent form. Exclusion Criteria: 1. Individuals with renal diseases, hepatic diseases, or those under pharmacological treatment for any condition associated with acute inflammation. 2. Individuals currently undergoing treatment for obesity (pharmacological, nutritional, or physical activity programs). 3. Individuals taking dietary supplements or multivitamins.