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NCT07780357
HCC Risk Prediction Model Based on Multimodal Data in Chronic Hepatitis B
Conditions: Hepatocellular Carcinoma (HCC)
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 2000
Sponsor: Beijing Friendship Hospital
Location: Beijing Friendship Hospital, Capital Medical University Beijing Xicheng
Summary
We propose to construct and validate an early HCC risk prediction model in a multicenter retrospective cohort of hepatitis B-related fibrosis/cirrhosis patients, using multimodal data encompassing longitudinal clinical data, serum glycomics profiles, and liver biopsy histopathological images.
Eligibility Criteria
Inclusion Criteria:
1. Aged ≥18 years, both sexes eligible.
2. Diagnosed with hepatitis B-related liver fibrosis or cirrhosis based on clinical assessment or liver histopathology.
3. Undergoing antiviral treatment.
4. Follow-up duration between 0.5- 5 years.
5. Availability of baseline data and at least two longitudinal follow-up visits.
6. Clinical outcomes during the follow-up period are traceable.
Exclusion Criteria:
1. Diagnosis of Hepatocellular carcinoma (HCC) or liver transplantation at baseline or within 6 months after baseline/enrollment.
2. Coexisting other chronic liver diseases, such as genetic/metabolic liver diseases, drug-induced liver injury, or severe steatotic liver disease.
3. Coexisting other malignancies (except those considered cured).
Source: ClinicalTrials.gov (NCT07780357). StuddyBuddy aggregates publicly available trial information.
