Exosome Injection Versus Topical Minoxidil for Androgenetic Alopecia

Androgenetic alopecia (AGA) is a common form of hair loss characterized by progressive hair follicle miniaturization. This prospective randomized comparative study evaluates the efficacy and safety of intradermal exosome injections compared with 5% topical minoxidil in patients with AGA. Forty patients were randomly assigned to receive either intradermal exosome injections or topical minoxidil for three months, with clinical, trichoscopic, patient-reported, and safety outcomes assessed at baseline, after treatment, and at 3-month follow-up.

Inclusion Criteria: * Were male or female patients with a confirmed diagnosis of androgenetic alopecia (AGA). Had not received any treatment for AGA for at least 6 months before study initiation. Provided written informed consent. Agreed to attend the scheduled follow-up assessments and undergo photographic documentation. Exclusion Criteria: * Concurrent scalp diseases. A history of bleeding disorders. Current use of anticoagulant medications. Known keloidal tendency. History of psoriasis or lichen planus. Significant cardiac, hepatic, or renal disease. Any major systemic illness. Pregnancy or lactation.