Efficacy Validation of Deep Microspicule Cream for Anti-aging and Whitening on Mature Skin

This study is a single-center, prospective, split-face self-controlled pilot trial designed to evaluate the anti-aging and whitening efficacy of the "Deep Microspicule Cream" (containing patented crystal microspicules encapsulating Penghu seaweed extract) on mature skin.

Inclusion Criteria: * Healthy male or female participants aged 40-65 years. * Presence of at least one facial aging or hyperpigmentation feature (e.g., eye area sagging, eye bags, crow's feet, fine lines, freckles, sun spots, uneven skin tone, or dullness). * Willing to complete 3 study visits within 4 weeks, comply with instrumental measurements, and maintain product logs. * Willing to sign the Informed Consent Form (ICF). Exclusion Criteria: * Received facial aesthetic treatments (e.g., lasers, chemical peels, microneedling, energy-based therapies) within 4 weeks. * Used topical/oral retinoic acid or strong whitening creams (e.g., high-concentration hydroquinone) within 4 weeks. * Severe sensitive skin, active atopic dermatitis, or obvious facial skin lesions/infections. * Facial salon or exfoliation treatments more frequent than once every 2 weeks. * Known allergy to seaweed-derived ingredients or product preservative systems. * Uncontrolled systemic diseases (e.g., diabetes, kidney/liver/cardiovascular diseases, severe infections, endocrine disorders, or cancer). * Pregnant, lactating, or planning to become pregnant. * Deemed unsuitable for participation by the investigator.