Uterine Lavage to Detect Ovarian Cancer Risk

Conditions: BRCA Hereditary Ovarian Carcinoma, Fallopian Tube High Grade Serous Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma, Primary Peritoneal High Grade Serous Adenocarcinoma

Sex: Female

Ages: 18 Years – N/A

Healthy volunteers: No

Phase: NA

Enrollment: 75

Sponsor: University of Washington

Location: Fred Hutch/University of Washington Cancer Consortium Seattle Washington

Summary

This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations. Women with inherited mutations in the BRCA1 and BRCA2 genes (BRCA carriers) have a much higher lifetime risk of developing ovarian cancer. Currently there are no effective ovarian cancer screening or early detection tests for BRCA carriers. Uterine lavage is a procedure that uses saline to rinse and collect cells from the fallopian tube. Molecular analysis of these samples may help proactively detect genetic alterations that are indicative of progression to ovarian cancer in women with BRCA mutations.

Eligibility Criteria

Inclusion Criteria: * \> 18 years of age * Have a pathogenic BRCA1 or BRCA2 germline variant * Planned risk-reduction surgery * Presence of uterus and at least one fallopian tube Exclusion Criteria: * Prior tubal ligation * Prior history of known ovarian or endometrial cancer

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07772869). StuddyBuddy aggregates publicly available trial information.