Ultrasonographic Evaluation of Cosmetic Keratolytic Treatment of Foot Calluses and Corns

This prospective, non-randomized, controlled study evaluated the efficacy of a topical cosmetic keratolytic preparation (serum and cream containing urea, salicylic acid, and collagen) in reducing the thickness and associated pain of hyperkeratotic foot lesions (calluses and corns). High-frequency ultrasonography (18 MHz) was used for precise, quantitative measurement of lesion thickness before and after a two-month intervention. Participants were allocated to four parallel groups (treated calluses, untreated callus controls, treated corns, and untreated corn controls).

Inclusion Criteria: * Adult women aged 35-65 years. * Presence of a single non-infectious hyperkeratotic foot lesion classified as either a callus or a corn. * Written informed consent provided prior to study initiation. Exclusion Criteria: * Known allergy or hypersensitivity to salicylic acid, salicylates, or other formulation ingredients. * Active dermatological conditions, skin diseases, or epidermal fissures on the lower extremities. * Diabetes mellitus. * Active cardiovascular disorders or local inflammatory conditions.