EUS-DFI in Solid Pancreatic Lesions

This prospective, international, multicenter observational study aims to evaluate the role of Endoscopic Ultrasound-guided Detective Flow Imaging (EUS-DFI) in the characterization of solid pancreatic lesions. The study will assess microvascularization patterns identified by EUS-DFI and their association with the final diagnosis, using histopathology or clinical follow-up as the reference standard. Secondary objectives include evaluating interobserver agreement and the diagnostic accuracy of DFI vascular patterns for differentiating benign and malignant pancreatic lesions.

Inclusion Criteria: * Adults aged 18 years or older. * Presence of a solid pancreatic lesion identified during endoscopic ultrasound (EUS), regardless of the indication for the examination. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Predominantly cystic pancreatic lesions. * Anatomical abnormalities preventing adequate EUS examination. * Limited ability to understand the study procedures or provide informed consent. * Refusal to sign the informed consent form.