Autologous Nanofat for Treatment of Atrophic Scars

A prospective, randomized, split-scar, within-participant controlled clinical study evaluating the efficacy and safety of a single session of autologous nanofat injection followed by topical silicone gel in the treatment of atrophic postburn or posttraumatic scars. Each participant will have two comparable scar areas/sites. One site will receive autologous nanofat injection followed by topical silicone gel, while the contralateral/comparable control site will receive topical silicone gel alone. Participants will be followed for 3 months, with assessments at baseline, 1 month, and 3 months.

Inclusion Criteria: * Adults aged 18 years or older. * Presence of clinically diagnosed atrophic postburn or posttraumatic scars. * Scars were stable and mature at the time of enrollment. * Presence of two comparable scar areas suitable for the split-scar study design. * Scar sites were suitable for standardized clinical and photographic assessment. * Participants were willing to undergo a single session of autologous nanofat injection. * Participants were able to comply with the study visits and 3-month follow-up. * Written informed consent was obtained before participation. Exclusion Criteria * Hypertrophic scars or keloids. * Active infection, inflammation, ulceration, or dermatitis at the selected scar sites. * Previous procedural treatment of the selected scar sites that could affect study assessment. * Significant uncontrolled systemic disease that could interfere with wound healing or treatment. * Bleeding disorders or other contraindications to the fat-harvesting or injection procedure. * Pregnancy or breastfeeding. * Known allergy or intolerance to the topical silicone gel used in the study. * Inability to provide informed consent or comply with study follow-up. * Any medical condition considered by the investigator to pose an unacceptable risk or interfere with study evaluation. Exclusion Criteria: \-