Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery

This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical extraction of impacted mandibular third molars. Sixty patients will be randomly allocated to one of four parallel groups: T-PRF, LLLT, T-PRF plus LLLT, or control. The primary outcomes include postoperative pain assessed using a visual analogue scale (VAS), analgesic consumption, postoperative swelling and trismus. The findings may help identify effective approaches for improving postoperative recovery after mandibular third molar surgery.

Inclusion Criteria: * Adults requiring surgical extraction of a unilateral vertically impacted mandibular third molar. * Healthy individuals (ASA I or II). * Ability to provide written informed consent. * Willingness to attend all follow-up visits. Exclusion Criteria: * Systemic disease affecting wound healing. * Pregnancy or lactation. * Active infection or acute pericoronitis. * Long-term opioid use. * Smoking and alcohol use. * Known allergy to study medications. * Previous radiotherapy to the head and neck region * Inability to attend follow-up visits.