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NCT07748351
A Clinical Trial of Multiple Formulations of MK-4082 in Healthy Overweight and Obese Participants (MK-4082-007)
Conditions: Healthy
Sex: All
Ages: 18 Years – 60 Years
Healthy volunteers: Yes
Phase: PHASE1
Enrollment: 48
Sponsor: Merck Sharp & Dohme LLC
Location: ProSciento Inc. ( Site 0002) Chula Vista California
Summary
Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) and formulation (version) of the study medicine that can be used in future studies.
The goals of this study are to learn about:
The safety of different formulations of MK-4082 and if people tolerate them What happens to different formulations of MK-4082 in a person's body over time
Eligibility Criteria
Inclusion Criteria:
The main inclusion criteria include but are not limited to the following:
* Is in good health
* Has a body mass index (BMI) between 25 and 40 kg/m\^2, inclusive and weighs at least 60 kg
Exclusion Criteria:
The main exclusion criteria include but are not limited to the following:
* Has a history of previous surgical treatment for obesity that may induce malabsorption, history of bowel resection \>20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss
* Has an individual or family history of medullary thyroid carcinoma or multiple endocrine neoplasia 2
Source: ClinicalTrials.gov (NCT07748351). StuddyBuddy aggregates publicly available trial information.