Efficacy of Topical Tyrosine Versus Topical 5-Fluorouracil With Fractional Erbium YAG Laser

Vitiligo is an autoimmune disorder affecting the skin, specifically targeting pigment-producing melanocytes, leading to noticeable regions of depigmentation characterized by white spots. It is a widely prevalent skin disorder globally, affecting males and females almost equally, although it is reported slightly more frequently in females. In more than 60% of patients, the disease begins before the age of 30 and It has an estimated prevalence of roughly 0.2-2% across various populations, with around 0.4% in the European-derived white (EUR) population.

Inclusion Criteria: \- Patients with focal vitiligo Exclusion Criteria: * Pregnancy. * Lactation. * Patients with segmental vitiligo. * Patients with autoimmune disease including thyroiditis. * Patients with chronic systemic diseases,such as anemia ,diabetes mellitus, immunosuppression, or chronic infections. * Patients with active skin infections.