Alveolar Ridge Preservation Using Acemannan Aloe Vera Versus Natural Socket Healing

The goal of this clinical trial is to evaluate the effectiveness of acemannan aloe vera powder extract in preserving the alveolar ridge following tooth extraction in healthy adult patients. It will also assess the healing process by radiographic and histomorphometric analyses. The main questions it aims to answer are: Does acemannan aloe vera powder extract improve alveolar ridge preservation compared with natural socket healing? Does the use of acemannan aloe vera powder extract enhance bone quality and new bone formation as assessed by radiographic and histomorphometric outcomes? Researchers will compare sockets treated with acemannan aloe vera powder extract to sockets allowed to heal naturally to determine whether the intervention results in improved dimensional preservation of the alveolar ridge and enhanced bone regeneration. Participants will: Undergo tooth extraction according to the study protocol. Be randomly assigned to receive either acemannan aloe vera powder extract for alveolar ridge preservation or natural socket healing without grafting. Attend scheduled follow-up visits for clinical and radiographic evaluations. Undergo radiographic assessment using cone-beam computed tomography (CBCT) to evaluate changes in alveolar ridge dimensions. Provide a bone biopsy at the time of implant placement for histomorphometric analysis of new bone formation and tissue composition.

Inclusion Criteria: * Non-restorable tooth in maxillary or mandibular anterior esthetic region. * Intact or minimally affected buccal plate of bone. * Patients at least 18 years or older. * Motivated patients, agree to sign the written informed consent and complete the follow-up period. Exclusion Criteria: * Infection at the extraction site. * Smokers more than 10 cigarettes per day . * Patients undergoing or having a history of radiotherapy, chemotherapy, or bisphosphonate therapy . * Systemic conditions that may compromise healing or bone metabolism (e.g., uncontrolled diabetes, hyperthyroidism) . * Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo/radio therapy) * Systemic diseases or medications that affect blood clotting * Pregnant females or those planning to get pregnant during the study period (American Dental Association, 2011).