Spinal Versus General Anesthesia on Coagulation and Fibrinolysis During Transurethral Resection of the Prostate

This prospective randomized clinical trial aims to compare the effects of spinal and general anesthesia on perioperative coagulation and fibrinolysis in patients undergoing elective transurethral resection of the prostate (TURP). Blood samples are collected before surgery and at 1 and 24 hours postoperatively to evaluate coagulation and fibrinolytic parameters. The study also assesses perioperative hemodynamic events and postoperative complications.

Inclusion Criteria: * Male patients * Age ≥18 years * Scheduled for elective bipolar transurethral resection of the prostate * ASA physical status I-II * Ability to provide written informed consent Exclusion Criteria: * History of deep vein thrombosis or pulmonary embolism * Known inherited or acquired coagulation disorder * Severe hepatic insufficiency * Severe renal insufficiency * Use of anticoagulants, antiplatelet drugs, or NSAIDs within 10 days before surgery * Platelet count \1.5 * aPTT \>47 seconds * Contraindications to spinal anesthesia * Prostate malignancy * ASA physical status III or higher * Refusal to participate