Effectiveness of Posluma PET Scan for Post-Treatment Monitoring of Prostate Cancer

To determine the effectiveness of Posluma PET Scan for monitoring prostate cancer patients after targeted treatment, including how accurately it can detect any remaining or returning cancer after about 12 months post-treatment.

Inclusion Criteria: 1. Diagnosis: Histologically confirmed PCa. 2. Risk Profile: Intermediate-risk , organ-confined PCa 3. Eligibility for Focal Therapy: Determined to be an appropriate candidate for focal therapy based on clinical evaluation. 4. Age: 18 years or older. 5. Life Expectancy: Expected survival of at least 10 years. 6. Informed Consent: Ability to understand and willingness to sign the informed consent form. Exclusion Criteria: 1. Previous Treatment: Prior treatment for PCa, including radiation therapy, chemotherapy, focal therapy, or androgen deprivation therapy. 2. Severe Comorbid Conditions: Presence of severe comorbid conditions that may interfere with study participation, such as uncontrolled cardiovascular, renal, hepatic, or metabolic diseases. 3. Contraindications to Imaging: Known hypersensitivity to components of the Posluma PSMA radiotracer, or inability to undergo PET or MRI imaging due to medical or anatomical constraints (e.g., severe claustrophobia, metallic implants incompatible with MRI).