Effect of Preoperative Carbohydrate Loading on Serum Lactate Levels in Patients Undergoing Donor Hepatectomy

Conditions: Donor Hepatectomy, Serum Lactate, Preoperative Carbohydrate Loading

Sex: All

Ages: 18 Years – 50 Years

Healthy volunteers: Yes

Phase: NA

Enrollment: 70

Sponsor: Shifa International Hospital

Summary

This randomized controlled trial investigated whether preoperative carbohydrate loading reduces perioperative serum lactate levels in patients undergoing donor hepatectomy. Participants were randomized into two groups: an intervention group receiving a standardized oral carbohydrate drink 2-4 hours before surgery, and a control group undergoing standard preoperative fasting. Serum lactate levels were measured at five perioperative time points: induction of anaesthesia, before graft removal, 30 minutes after graft removal, before extubation, and in the post-anaesthesia care unit. The study aimed to determine whether this simple nutritional intervention could improve metabolic preparedness and reduce anaerobic stress in living liver donors.

Eligibility Criteria

Inclusion Criteria: * Age 18 to 50 years Either gender Scheduled for elective donor hepatectomy Exclusion Criteria: * Known metabolic disorders Pre-existing liver dysfunction

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07723391). StuddyBuddy aggregates publicly available trial information.