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NCT07718048
Acute Effects of MCT Formulations on Beta-Hydroxybutyrate Response, Lipid Profile, and Glucose Levels in Healthy Adults
Conditions: Ketone Body, Lipid Metabolism, Glucose Response
Sex: All
Ages: 18 Years – 40 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 12
Sponsor: University of Milan
Location: International Center for the Assessment of Nutritional Status and the development of Dietary Intervention Strategies (ICANS-DIS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan Milan
Summary
The goal of this clinical trial is to evaluate the effects of medium-chain triglycerides (MCTs), delivered in different formulations, on beta-hydroxybutyrate response (as a marker of ketone body production), lipid metabolism, and glucose responses in healthy adults.
The main questions it aims to answer are:
Do MCTs influence beta-hydroxybutyrate responses, lipid metabolism, and glucose responses differently compared to long-chain triglycerides (LCTs)?
Do different types of MCTs (natural sources containing C8 to C12 versus synthetic formulations containing only C8 and C10) lead to different beta-hydroxybutyrate, lipid, and glucose responses?
Does the form in which MCTs are consumed (e.g., powders or incorporated into foods) influence beta-hydroxybutyrate production, lipid metabolism, and glucose responses?
Researchers will compare five different lipid formulations to evaluate their effects on postprandial beta-hydroxybutyrate concentrations, blood lipid levels, and glucose.
Participants will:
Consume five different test products on separate study visits. Provide blood samples for up to five hours after each intake for metabolic measurements.
Eligibility Criteria
Inclusion Criteria:
* Healthy adult participants
* Age between 18 and 40 years
* Ability to understand the study procedures and provide informed consent
Exclusion Criteria:
* Alterations in glucose or lipid metabolism
* Diseases requiring the use of medications that affect glucose or lipid metabolism
* Reported or diagnosed malabsorption conditions
* Pregnancy or breastfeeding
Source: ClinicalTrials.gov (NCT07718048). StuddyBuddy aggregates publicly available trial information.