Assessment of Endocrine and Metabolic Late Effects After Childhood Brain Tumor Treatment

This prospective, single-group interventional study evaluates endocrine and metabolic late effects in survivors of primary brain tumors treated during childhood. According to the study protocol, participants were prospectively assigned to undergo the Study-Specific Endocrine and Metabolic Late-Effects Assessment. The assessment included anthropometric measurements, repeated blood pressure measurements, clinical endocrine evaluation, fasting laboratory testing, and protocol-defined bone and vascular assessments. The purpose of the study was to identify the frequency and severity of endocrine and metabolic late effects and to evaluate their associations with tumor characteristics, previous cancer treatment, age at diagnosis, and physical functioning.

Inclusion Criteria: * Individuals treated for a primary brain tumor in Slovenia between 2008 and 2018 while aged 0 to 18 years. * Survival for at least 5 years after the diagnosis of a primary brain tumor. * Written informed consent provided by the participant or, when applicable, by a parent or legal guardian. Exclusion Criteria: * Failure to meet the inclusion criteria. * Absence of written informed consent from the participant or, when applicable, from a parent or legal guardian.