Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery

Sex: Female

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 50

Sponsor: Medipol University

Summary

This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels will be measured and normalized to urinary creatinine. Biomarker changes will be compared between patients undergoing surgery in 30° and 45° Trendelenburg positions. The study seeks to determine whether these biomarkers can detect early renal injury before clinically significant changes in serum creatinine occur.

Eligibility Criteria

Inclusion Criteria: Female participants aged 18 years or older. Scheduled for elective gynecological laparoscopic surgery. Expected duration of pneumoperitoneum of at least 90 minutes. Planned intraoperative Trendelenburg position of approximately 30° or 45°. Ability to provide written informed consent. - Exclusion Criteria: Age younger than 18 years. Pre-existing chronic kidney disease (estimated glomerular filtration rate \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07704242). StuddyBuddy aggregates publicly available trial information.