Effects of Using Advanced NEUROrehabilitation TECHnologies in Upper Limb Motor Function and Capacity Recovery in People With Stroke

This study aims to evaluate the effect of a personalized technology-based rehabilitative intervention on Upper Limb (UL) motor function and capacity recovery in People with Stroke (PwS). The study is single-cohort study in which eligible participants will undergo baseline and follow-up clinical and instrumental assessments over a 4-5 week period. The intervention consists of a personalized and specific upper limb technology-based rehabilitation programme delivered three times per week for a total of 12-15 sessions. Each session lasts approximately one hour and is integrated with conventional rehabilitation treatments. Primary outcomes include Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and Action Research Arm Test (ARAT). Secondary outcomes include instrumental assessment of active range of motion and grip strength.

Inclusion Criteria: * Age ≥ 18 years; * First-ever unilateral ischemic or hemorrhagic stroke; * Presence of upper limb motor impairment; * Modified Ashworth Scale (MAS) \< 3; * Montreal Cognitive Assessment (MoCA) \> 24; * Medically stable and able to participate in an intensive rehabilitation programme; * Ability to understand and follow study procedures; * Written informed consent. Exclusion Criteria: * Diagnosis of severe aphasia, based on medical records, preventing participation; * Bilateral hemisphere lesions; * Severe and unstable medical conditions (e.g. untreated seizure, heart failure) that preclude participation in rehabilitation; * Other neurological and/or psychiatric diseases; * Recent and unstabilized upper limb fracture.