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NCT07688551
Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
Conditions: Aphasia, Broca's Aphasia
Sex: All
Ages: 25 Years – 80 Years
Healthy volunteers: No
Phase: PHASE2, PHASE3
Enrollment: 130
Sponsor: University of South Carolina
Location: Medical University of South Carolina Charleston South Carolina
Summary
The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.
Eligibility Criteria
Inclusion Criteria:
* Be willing and able to give informed consent.
* Be willing and able to comply with study requirements.
* Be between 25 and 80 years of age.
* Have used English as the primary language for \> 15 years.
* Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan.
* Be greater than 6 months post-stroke.
* Have Broca's aphasia diagnosed by the WAB-R (fluency score ≤ 5, auditory verbal comprehension score 4-10, repetition score 0-7.9, naming and word finding score \< 9).
* Correctly name 140 or fewer items on the PNT.
Exclusion Criteria:
* History of brain surgery except for during the treatment of the acute stroke.
* Seizures during the previous 12-months.
* Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection).
* Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test).
* Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below.
* Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal implants or electrical stimulators.
* Participants with continuous oxygen therapy which cannot be discontinued for more than 1 hour.
* Any condition or situation that the PI determines would significantly interfere with the participant's ability to complete the study.
Source: ClinicalTrials.gov (NCT07688551). StuddyBuddy aggregates publicly available trial information.