CBCT Assessment of Marginal Bone Changes With Ozone Therapy

This study examined whether adding local gaseous ozone to standard dental implant treatment could reduce early bone loss around implants. Fifty adults requiring matched implants on opposite sides of the same jaw participated. Within each participant, matched implant sites were randomly assigned to ozone treatment or standard treatment without ozone. Ozone was applied to the prepared implant socket during surgery and to the peri-implant surgical site after suturing and on postoperative days 1, 3, 5, and 7. Changes in marginal bone levels from baseline to 6 months were assessed using cone-beam computed tomography (CBCT).

Inclusion Criteria: * Adults aged 18 to 65 years. * Systemically healthy individuals. * Ability to comply with the study procedures and follow-up visits. * Requirement for implant placement at matched contralateral posterior sites within the same jaw. * Healed edentulous sites suitable for conventional implant placement. * Adequate alveolar bone volume for placement of implants measuring 3.5-4.0 mm in diameter and 8-12 mm in length without the need for advanced bone augmentation, with at least 1.5 mm of surrounding bone. * Initial soft-tissue thickness of at least 2 mm and keratinized mucosal width of at least 2 mm at the implant sites. * Provision of written informed consent. Exclusion Criteria: * Systemic diseases or medical conditions contraindicating implant surgery. * Pregnancy. * Smoking. * Active oral infection or advanced periodontal disease. * Insufficient bone volume requiring advanced bone augmentation. * Incomplete healing at the intended implant site following recent tooth extraction. * Previous implant failure at the intended implant site. * Any contraindication to ozone therapy.