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NCT07683962
Influence of Early Wound Healing on the Outcomes of Regenerative Periodontal Surgery
Conditions: Intrabony Periodontal Defect, Wound Healing
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 100
Sponsor: University of Roma La Sapienza
Location: Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology Rome Rome
Summary
This study investigates whether early post-surgical healing (1-2 weeks) affects the 12-month clinical and radiographic success of periodontal regenerative therapy in patients with Stage III-IV periodontitis.
Eligibility Criteria
Inclusion Criteria:
* Diagnosis of Stage III or IV Periodontitis.
* Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth \[PPD\] \>= mm, radiographic depth \>= 3 mm).
* Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) \< 15% at the time of surgery.
Exclusion Criteria:
* Systemic: ASA III-VI classification; uncontrolled diabetes; medications causing gingival overgrowth (e.g., nifedipine, cyclosporine, phenytoin); heavy smokers (\>10 cigarettes/day); pregnancy or lactation.
* Local: Third molars; Grade III tooth mobility; inadequate endodontic treatment; teeth undergoing orthodontic treatment; teeth supporting removable or implant-linked fixed prosthetics.
Source: ClinicalTrials.gov (NCT07683962). StuddyBuddy aggregates publicly available trial information.
