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Recruiting
NCT07679828
Polypills Approach for Multiple Cardiovascular Risk Factors
Conditions: Hypertension, Dyslipidemia, Diabetes
Sex: All
Ages: 50 Years – 75 Years
Healthy volunteers: No
Phase: NA
Enrollment: 8252
Sponsor: China Medical University, China
Location: The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou Henan
Summary
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated management of hypertension, dyslipidemia, and type 2 diabetes among adults aged 50 to 75 years without prior cardiovascular disease in China. The trial will evaluate whether a fixed-dose combination strategy improves the 10-year cardiovascular disease risk estimated using the PREVENT equations at Phase 1. Participants will be further followed to determine whether the fixed-dose combination strategy reduces major cardiovascular events and improves cognitive outcomes compared with usual care at Phase 2.
Eligibility Criteria
Inclusion Criteria:
* Men or women
* Age ≥50 years and \
Source: ClinicalTrials.gov (NCT07679828). StuddyBuddy aggregates publicly available trial information.
