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Available
NCT07675057
Expanded Access for Vepugratinib (LY3866288) in Participants With Fibroblast Growth Factor Receptor 3 (FGFR3) Altered Solid Tumors
Conditions: Urinary Bladder Neoplasms, Neoplasm Metastasis, Carcinoma, Transitional Cell
Sex: All
Ages: 18 Years – N/A
Sponsor: Eli Lilly and Company
Summary
The treating physician/investigator contacts Lilly when, based on their medical opinion, a patient meets the criteria for inclusion in the expanded access program.
Eligibility Criteria
Inclusion Criteria:
* Have metastatic urothelial carcinoma (UC) or other solid tumor with a qualifying fibroblast growth factor receptor 3 (FGFR3) genetic alteration.
* Have exhausted other approved treatments, including erdafitinib for UC.
* Are not eligible for an ongoing vepugratinib clinical trial
Exclusion Criteria:
* Currently enrolled in an ongoing clinical study of vepugratinib
* Have a known severe (greater than or equal to (≥) Grade 3) hypersensitivity to any component or excipient of vepugratinib.
* Current evidence of corneal keratopathy or retinal disorder confirmed by ocular examination. Exception: Individuals with asymptomatic ophthalmic conditions assessed by the investigator to pose minimal risk.
* Significant cardiovascular disease:
* Are pregnant, breastfeeding, or intent to become pregnant during the study or within 6 months of the last dose of study intervention.
Source: ClinicalTrials.gov (NCT07675057). StuddyBuddy aggregates publicly available trial information.