Epidemiological Evaluation Of Chronic Kidney Disease In Pediatric Patients With Inflammatory Bowel Disease

This multicenter observational cross-sectional study aims to evaluate the prevalence of chronic kidney disease (CKD) in pediatric patients with inflammatory bowel disease (IBD) and to compare it with a control group without IBD. Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are chronic conditions that can also affect organs outside the intestine. Among these, kidney involvement has been reported, but data in pediatric populations are limited. The study will collect clinical, laboratory, and demographic data from pediatric patients with IBD and matched controls without IBD. The main objective is to estimate the prevalence of CKD in children with IBD and compare it with that observed in the control group. Secondary objectives include describing patient characteristics and exploring potential associations between CKD, disease activity, and medical therapies. The results of this study may improve the understanding of kidney complications in pediatric IBD and support earlier diagnosis and better clinical management.

Inclusion Criteria: * Pediatric patients aged between 2 and 17 years * For the case group: confirmed diagnosis of inflammatory bowel disease according to Porto criteria * For the control group: absence of current or previous diagnosis of inflammatory bowel disease * Availability of clinical and laboratory data required for study evaluation * Written informed consent from parent or legal guardian, and assent from the minor when applicable Exclusion Criteria: * History of pre-existing renal disease (congenital or acquired before IBD diagnosis) * Presence of conditions that may affect renal function (e.g., diabetes mellitus, hypertension, chronic use of nephrotoxic drugs) * Lack of informed consent