← Back to all trials
Completed
NCT07669402
Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia.
Conditions: Idiopathic Oligoasthenoteratozoospermia, Male Infertility
Sex: Male
Ages: 20 Years – 45 Years
Healthy volunteers: No
Phase: PHASE2, PHASE3
Enrollment: 90
Sponsor: Tehran University of Medical Sciences
Location: Shariati Hospital, Tehran University of Medical Sciences Tehran
Summary
This is a randomized clinical trial evaluating the efficacy of Letrozole, L-Carnitine, and their combination on sperm quality, oxidative stress, and ART outcomes in men with idiopathic oligoasthenoteratozoospermia.
Eligibility Criteria
Inclusion Criteria:
Diagnosis of idiopathic oligoasthenoteratozoospermia (iOAT) per WHO 2021 criteria
Age 20 to 45 years
BMI between 18 and 30 kg/m²
No prior hormonal therapy or antioxidant supplements within the last 3 months
Exclusion Criteria:
Varicocele, cryptorchidism, or genital tract infection
Hormonal disorders (hypogonadism, hyperprolactinemia, thyroid dysfunction)
Smoking, alcohol use, or drug abuse
Use of testosterone or anabolic steroids within the last 6 months
Female partner with severe infertility factors (age ≥40, tubal blockage, severe endometriosis)
Source: ClinicalTrials.gov (NCT07669402). StuddyBuddy aggregates publicly available trial information.
