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NCT07656454
A Study Understanding How Much CDR132L Enters the Bloodstream After Injection Under the Skin Compared to Injection Into a Vein in Healthy Participants
Conditions: Healthy Volunteers, Heart Failure
Sex: All
Ages: 18 Years – 55 Years
Healthy volunteers: Yes
Phase: PHASE1
Enrollment: 32
Sponsor: Novo Nordisk A/S
Location: Parexel International GmbH Berlin
Summary
This study is being done to understand how much of the medicine (CDR132L) enters the bloodstream after injection under the skin compared to injection into a vein in healthy people. This will help us find the best way to give the medicine to people living with heart failure. The study will assess what the body does to the medicine, and how safe it is.
Eligibility Criteria
Inclusion Criteria:
* Male or female (sex at birth).
* Age 18-55 years (both inclusive) at the time of signing the informed consent.
* Body mass index 18.5-29.9 kilograms per square metre (kg/m\^2) (both inclusive) and body weight less than or equal to (≤) 120 kilograms (kg) at screening (visit 1).
* Considered to be generally healthy based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit (visit 1), as judged by the investigator.
Exclusion Criteria:
* Any laboratory safety parameters at screening (visit 1) outside the below laboratory ranges, see laboratory manual for specific values.
* Alanine aminotransferase (ALT) greater than (\>) upper limit of normal (ULN) +10 percentage (%)
* Aspartate aminotransferase (AST) \>ULN +20%
* Bilirubin \>ULN +20%
* Creatinine \>ULN +10%
* Estimated glomerular filtration rate (eGFR) (Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\]) less than (\
Source: ClinicalTrials.gov (NCT07656454). StuddyBuddy aggregates publicly available trial information.