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Completed
NCT07655648
Dual-tracer PET Radiomics for Prostate Cancer Stratification
Conditions: Prostate Cancer, Gleason Score, PET/CT, Radiomics, Biochemical Recurrence
Sex: Male
Healthy volunteers: No
Enrollment: 100
Sponsor: Xiangya Hospital of Central South University
Location: Department of Nuclear Medicine, Xiangya Hospital, Central South University Changsha Hunan
Summary
This single-center retrospective study aims to develop an interpretable radiomics model based on dual-tracer PET/CT to preoperatively predict the postoperative pathological Gleason grade group in treatment-naïve prostate cancer patients. A machine learning-based three-class prediction model will be constructed and interpreted using SHAP. Its performance will be compared with systematic biopsy results, assessing grading accuracy and prognostic value for biochemical recurrence-free survival.
Eligibility Criteria
Inclusion Criteria:
* Treatment-naïve prostate cancer with subsequent radical prostatectomy (RP)
* Availability of presurgical dual-tracer PET/CT images, biopsy, and RP pathology data
Exclusion Criteria:
* Unavailability of imaging or pathological data
* PET/CT performed after any prostate cancer-related treatment
* Interval between PET and biopsy \> 3 months
* Interval between biopsy and RP \> 1 month
Source: ClinicalTrials.gov (NCT07655648). StuddyBuddy aggregates publicly available trial information.
