The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions

Conditions: Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease

Sex: All

Ages: 18 Years – 60 Years

Healthy volunteers: Yes

Phase: NA

Enrollment: 120

Sponsor: Istanbul Medipol University Hospital

Location: Istanbul Medipol University, Faculty of Dentistry, Department of Endodontics Istanbul

Summary

This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with combined endodontic-periodontal (endo-perio) lesions. The study compares MTA with resin-based sealers and evaluates clinical, radiographic, and biochemical outcomes, including levels of IL-10, TNF-α, and MMP-8 in gingival crevicular fluid. The ultimate goal is to determine which treatment approach improves healing and increases tooth survival in such complex lesions.

Eligibility Criteria

Inclusion Criteria: * Aged between 18 and 60 years Systemically healthy individuals Presence of radiographically confirmed periapical lesion Diagnosis of apical periodontitis and/or combined endodontic-periodontal lesion Ability to understand and sign informed consent Willingness to attend follow-up visits Exclusion Criteria: * Patients with severe systemic diseases (ASA III-VI) Teeth with advanced mobility (Miller Class III or higher) Patients unable to tolerate dental treatment procedures Patients unwilling to participate or attend follow-up visits

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07653997). StuddyBuddy aggregates publicly available trial information.