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NCT07653659
Hemodynamic Effects of Norepinephrine Reduction on Critical Closing Pressure in Distributive Shock
Conditions: Distributive Shock, Hemodynamic Assessment, Critical Illness
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 30
Sponsor: Peking Union Medical College Hospital
Location: Peking Union Medical College Hospital Beijing Beijing Municipality
Summary
This study prospectively observes changes in critical closing pressure (Pcc) and derived hemodynamic parameters in mechanically ventilated distributive shock patients when clinically indicated norepinephrine dose reduction is performed by the attending physician. Pcc is measured before and 30 minutes after dose reduction using a stepwise inspiratory hold maneuver via PiCCO monitoring.
Eligibility Criteria
Inclusion Criteria:
1. Adult distributive shock patients aged ≥18 years;
2. Receiving norepinephrine infusion with MAP in the 75-85 mmHg range;
3. PiCCO catheter in situ;
4. Under mechanical ventilation;
5. Clinically indicated norepinephrine dose reduction per attending physician judgment.
Exclusion Criteria:
1. Significant cardiac arrhythmia affecting CO measurement reliability;
2. Contraindication to airway plateau pressure maneuver;
3. Active titration of other vasoactive agents within 30 minutes prior to measurement;
4. Hemodynamic instability making it impossible to reduce norepinephrine dose.
Source: ClinicalTrials.gov (NCT07653659). StuddyBuddy aggregates publicly available trial information.
