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NCT07653464
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Conditions: Obesity (BMI>30), Insulin Resistance
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: EARLY_PHASE1
Enrollment: 64
Sponsor: University of Missouri-Columbia
Location: University of Missouri Columbia Missouri
Summary
In the present study, we seek to determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
Eligibility Criteria
Inclusion Criteria:
* 18 to 65 years of age
Individuals with obesity and comorbid IR
* BMI 30-45 kg/m2
* Waist circumference ≥102 cm (men) or ≥88 cm (women)
* HOMA-IR ≥2.5
Healthy normal weight adults
* BMI 18-25 kg/m2
* Waist circumference \10% within the last 6 months
* Adherence to \>150 min/week of moderate-to-vigorous physical activity/exercise
* Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months
* Claustrophobia
* Non-MRI compatible metal implants
Source: ClinicalTrials.gov (NCT07653464). StuddyBuddy aggregates publicly available trial information.
