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Not Yet Recruiting NCT07639333

GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA

Conditions: Miscarriage in First Trimester, Prenatal Genetic Diagnosis

Sex: Female
Ages: 18 Years – 43 Years
Healthy volunteers: No
Phase: NA
Enrollment: 100
Sponsor: Rennes University Hospital

Location: CHU Rennes Rennes

Summary

The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage

Eligibility Criteria

Inclusion Criteria: * A stopped pregnancy with an intrauterine pregnancy diagnosed by ultrasound (embryo larger than 7 mm corresponding to a gestational age of 6 weeks and 5 days. This is justified by the fact that fetal fragment (FF) detection is possible at 5 weeks of gestation, or 7 weeks and 5 days) * Expulsion of a pregnancy within the last 2 hours * Patient fluent in French * Enrolled in a social security program * Has received oral and written information about the protocol and has signed a consent form to participate in this research. Exclusion Criteria: * Diagnosis of an empty gestational sac, ectopic pregnancy, or unknown location * Ultrasound findings consistent with a molar pregnancy * Identified cause (preimplantation diagnosis, multiple uterine fibroids or a single fibroid \> 5 cm, uterine malformation affecting the uterine cavity, lupus, and antiphospholipid syndrome) * Inability to obtain a blood sample * Known current malignant tumor * Blood transfusions within the last 3 months * Cell therapy or immunotherapy within the last 3 months * Previous organ transplant

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07639333). StuddyBuddy aggregates publicly available trial information.