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NCT07639333
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
Conditions: Miscarriage in First Trimester, Prenatal Genetic Diagnosis
Sex: Female
Ages: 18 Years – 43 Years
Healthy volunteers: No
Phase: NA
Enrollment: 100
Sponsor: Rennes University Hospital
Location: CHU Rennes Rennes
Summary
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
Eligibility Criteria
Inclusion Criteria:
* A stopped pregnancy with an intrauterine pregnancy diagnosed by ultrasound (embryo larger than 7 mm corresponding to a gestational age of 6 weeks and 5 days. This is justified by the fact that fetal fragment (FF) detection is possible at 5 weeks of gestation, or 7 weeks and 5 days)
* Expulsion of a pregnancy within the last 2 hours
* Patient fluent in French
* Enrolled in a social security program
* Has received oral and written information about the protocol and has signed a consent form to participate in this research.
Exclusion Criteria:
* Diagnosis of an empty gestational sac, ectopic pregnancy, or unknown location
* Ultrasound findings consistent with a molar pregnancy
* Identified cause (preimplantation diagnosis, multiple uterine fibroids or a single fibroid \> 5 cm, uterine malformation affecting the uterine cavity, lupus, and antiphospholipid syndrome)
* Inability to obtain a blood sample
* Known current malignant tumor
* Blood transfusions within the last 3 months
* Cell therapy or immunotherapy within the last 3 months
* Previous organ transplant
Source: ClinicalTrials.gov (NCT07639333). StuddyBuddy aggregates publicly available trial information.