Prediction of Labor Induction Outcome in Nulliparous Women

Conditions: Nulliparous Patient With Unfavourable Cervix, Undergoing Labor Induction at Term ≥ 39SA

Sex: Female

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 190

Sponsor: Assistance Publique - Hôpitaux de Paris

Location: AP-HP - Hôpital Cochin - Maternité Port-Royal Paris Île-de-France Region

Summary

Labor induction rates are increasing worldwide, yet nulliparous patients remain at high risk of failed induction and intrapartum cesarean delivery as well as prolonged labor which are associated with increased maternal morbidity, adverse outcomes in future pregnancies, increased neonatal morbidity and negative childbirth experience. This study aims to evaluate whether macrophage activation biomarkers in cervicovaginal secretions can predict successful labor induction in low-risk nulliparous women at term with an unfavorable cervix (Bishop score \

Eligibility Criteria

Inclusion Criteria: * Age ≥ 18 years * Singleton pregnancy * Gestational age ≥ 39 weeks * Nulliparous * Live foetus * Cephalic presentation * Intact membranes * Bishop score \< 6 * Willing to participate in the study Exclusion Criteria * A minor or a protected adult (under guardianship or conservatorship) * Individuals who don't speak French or are not accompanied by a third party who speaks French * Suspected intrauterine fetal growth restriction (estimated fetal weight \< 3rd percentile or \< 10th percentile with abnormal fetal Doppler) * Presence of fetal malformations and/or genetic or chromosomal abnormalities

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07637318). StuddyBuddy aggregates publicly available trial information.